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CBD Pain Cream

   
Pain Cream CBD

In pain? This cream may provide relief!  
We are pleased to be able to offer you CBD Pain Cream in a 2-oz. size jar. 

Chronic pain represents an emerging public health issue of massive proportions, particularly in view of aging populations in industrialized nations. In Europe, chronic musculoskeletal pain of a disabling nature affects over one in four elderly people, while figures from Australia note that over half of older people suffer persistent pain, and up to 80% in nursing home populations. Responses to an ABC News poll in the USA indicated that 19% of adults (38 million) have chronic pain, and 6% (or 12 million) have utilized cannabis in attempts to treat it.

Available opiates, antidepressants and anticonvulsant drugs are providing inadequate relief. Physicians have been seeking new approaches to treatment of these conditions but many remain concerned about increasing governmental scrutiny of their prescribing practices, prescription drug abuse or diversion.

The introduction of cannabinoid medicines offers a novel approach to the issue of chronic pain management, offering new hope to many!

Cannabidiol, a non-euphoriant phytocannabinoid common in certain strains, shares neuroprotective effects with THC, inhibits glutamate neurotoxicity, and displays antioxidant activity greater than ascorbic acid (vitamin C) or tocopherol (vitamin E).

Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana.

In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. There is a growing body of preclinical and clinical evidence to support use of CBD oils for many conditions, suggesting its potential role as another option for treating challenging chronic pain or opioid addiction.

 

$40.45
Includes FREE SHIPPING!
Shipping on all international orders will be calculated at time of shipment.  Please call or email us for a quote. Sorry, no discounts on international orders.

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The Piedmont Naturals Organics Difference:
Why Buy Our CBD?

There’s no denying that CBD has risen in popularity in recent years. That popularity, however, means that many different CBD companies and manufacturers have entered into the industry. With so many different companies out there, how do you choose the right one?

Here are a few of the qualities that make
Piedmont Naturals the best place to turn to
for your CBD needs:

1. Our Products Are Backed With a Complete Money-Back Guarantee — We are so confident in the quality of our CBD products that if you’re not completely satisfied with them for whatever reason, we will provide you with a complete money-back guarantee.

2. Our Products Are Naturally Derived — At Piedmont Naturals, we believe in making sure our customers are accessing only the highest-quality natural CBD products.

3.  Guaranteed Clean - Our CBD is chemical-free, pesticide-free and THC-free.

4. Quality Control  - Our Products Are made in small batches by our own lab and by our Licensed Compounding Pharmacist.

5. Lab Tested - Piedmont Naturals CBD products are lab tested to make sure they contain the most beneficial cannabinoids

   

What can CBD Pain Cream possibly do?
* Relieve pain by binding to CB1 receptors while reducing swelling and inflammation
* Reduce social anxiety , cognitive impairment, and discomfort in patients diagnosed with Generalized * Social Anxiety Disorder (SAD)
* Improve sleep quality , so you get a full night’s rest and wake up refreshed with more energy
* Increase memory, focus, and mental acuity
* Combat neurodegenerative disorders like Alzheimers by removing plaque that block neuron-signaling
* Reduce cigarette, drug, & alcohol addiction by modulating the rewarding effects of addictive compounds
* Regulate blood sugar
* Provide relief to those suffering from IBD (Crohn’s or Colitis) through it's anti-inflammatory effects
* Improve symptoms of MS (multiple sclerosis) by providing durable protection to neurons
* Work to help eliminate fat by reducing appetite and cravings
* Reduce muscle spasms and cramps

Here are a couple of research studies done regarding CBD oil:

Apoptosis of malignant neoplasmsStudy source
Cannabidiol (CBD), a phytocannabinoid derived from Cannabis sativa, has anti-inflammatory and anti-oxidant properties, and displays anti-proliferative activity. Here we report a novel role for CBD as a potent inhibitor of EMV release from three cancer cell lines: prostate cancer (PC3), hepatocellular carcinoma (HEPG2) and breast adenocarcinoma (MDA-MB-231).

CBD significantly reduced exosome release in all three cancer cell lines, and also significantly, albeit more variably, inhibited microvesicle release.

We suggest that the known anti-cancer effects of CBD may partly be due to the regulatory effects on EMV biogenesis, and thus CBD poses as a novel and safe modulator of EMV-mediated pathological events.


Arthritis / inflammatory disordersStudy source
Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation and pain without side-effects, but CBD is hydrophobic and has poor oral bioavailability. Topical drug application avoids gastrointestinal administration, first pass metabolism, providing more constant plasma levels.

This study examined efficacy of transdermal CBD for reduction in inflammation and pain, assessing any adverse effects in a rat complete Freund’s adjuvant-induced monoarthritic knee joint model. CBD gels (0.6, 3.1, 6.2 or 62.3 mg/day) were applied for 4 consecutive days after arthritis induction. Joint circumference and immune cell invasion in histological sections were measured to indicate level of inflammation. Paw withdrawal latency (PWL) in response to noxious heat stimulation determined nociceptive sensitization, and exploratory behaviour ascertained animal’s activity level.

Measurement of plasma CBD concentration provided by transdermal absorption revealed linearity with 0.6–6.2 mg/day doses. Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner. PWL recovered to near baseline level. Immunohistochemical analysis of spinal cord (CGRP, OX42) and dorsal root ganglia (TNFα) revealed dose-dependent reductions of pro-inflammatory biomarkers. Results showed 6.2 and 62 mg/day were effective doses. Exploratory behaviour was not altered by CBD indicating limited effect on higher brain function.

These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.

 

 
 
   

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